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KMID : 0854720070270010061
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Korean Journal of Asthma, Allergy and Clinical Immunology
2007 Volume.27 No. 1 p.61 ~ p.65
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A Case of Myeloproliferative Variant of Hypereosinophilic Syndrome with Increased Serum Tryptase Evolving into Chronic Eosinophilic Leukemia
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Lee Sang-Pyo
Koh Kwang-Il
Park Se-Hoon
Jeong Sung-Hwan
Ahn Jeong-Yeal
Park Jung-Won
Bang Su-Mi
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Abstract
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A 72-year-old male patient was referred to the hematologic department because of persistent hypereosinophilia, splenomegaly and chronic fatigue; these existed for 3 months. A presumptive diagnosis of a myeloproliferative variant of hypereosinophilic syndrome was made on the basis of anemia, splenomegaly, bone marrow hypercelluarity, increased serum tryptase and vitamine B12. Fip 1 like 1-platelet- driven growth factor receptor alpha fusion gene and platelet- driven growth factor receptor beta gene rearrangement anal-ysis with RT PCR were negative. In initial therapeutic approach with prednisolone, hydroxyurea, and imatinib mesyalte, blood eosniophilia did not improve and transformation into chronic eosinophilic leukemia observed in the peripheral blood smear. In the case herein reported, therapeutic response was not achieved with cytosine arabinoside chemotherapy.
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KEYWORD
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Hypereosinophilia, Leukemia, Myeloproliferation
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